Blar i forfatter "Lund, Trine"
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Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men
Brovold, Henrik; Lund, Trine; Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Ytrehus, Kirsti; Zykova, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-19)Several epidemiological studies have pointed at serum uric acid (SUA) as an independent risk factor for mortality, diabetes, hypertension, cardiovascular and kidney disease; however, no clear pathogenic pathway is established. Uric acid (UA) crystals show pro-inflammatory properties and can thus create or contribute to the state of chronic low-grade inflammation, a widely accepted pathogenic mechanism ... -
Gene expression, function and ischemia tolerance in male and female rat hearts after sub-toxic levels of Angiotensin II
Aljabri, Mohammad Belal; Lund, Trine; Høper, Anje Christina; Andreasen, Thomas Vennø; Al-Saad, Samer; Lindal, Sigurd; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress
Boardman, Neoma Tove; Falck, Aleksander Tank; Lund, Trine; Chu, X; Martin, Armas Maria Montserrat; Norvik, Jon Viljar; Jenssen, Trond Geir; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-14)Uric acid is a purine degradation product but also an important antioxidant and ROS scavenger. Experimental settings that mimic myocardial ischemia-reperfusion have not included uric acid despite that it is always present in human extracellular fluid and plasma. We hypothesized that uric acid has an important role in myocardial ROS scavenging. Here, we tested the cardiac response to uric acid on ... -
Improved Cardiac Metabolism Following in Vivo Treatment of Type 2 Diabetic Mice with Fenofibrate Depends on Reduction of Plasma Lipids, as Well as Glucose
Severson, David L.; Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne D.; Lund, Trine; Larsen, Terje S. (Journal article; Tidsskriftartikkel, 2009-01-16)The plasma supply of energy substrates plays a key role in determining the cardiac metabolic phenotype. In diabetes, a high plasma supply of fatty acids (FA) leads to a predominant oxidation of FA for energy production, while glucose oxidation is markedly suppressed. The db/db mouse is a well accepted model of type 2 diabetes, showing hyperglycemia, hyperlipidemia, and hyperinsulinemia. Hearts from ...